Molecular and Cellular Iron Transport
Edited by Douglas Templeton
This text analyzes the molecular mechanisms, chemical behaviour and regulation of iron transport in biological systems and offers novel methods for the assessment of iron transport across biological membranes. It details the characteristics and consequences of iron deficiency and excess to prevent diseases affecting major organ structures and promote bodily iron homeostasis.
Preface
Contributors
I. Molecular Aspects of Iron Transport
Iron chemistry / Wesley R. Harris
Transferrins / Ross T.A. MacGillivray and Anne B. Mason
Transferrin receptor / Caroline A. Enns
Molecular aspects of release of iron from transferrin / Qing-Yu He and Anne B. Mason
Ferritins : structural and functional aspects / Paolo Arosio and Sonia Levi
Divalent metal-ion transporter (DCT1/DMT1/Nramp2) / Hiromi Gunshin and Matthias A. Hediger
Basolateral transport of iron in mammalian intestine: from physiology to molecules / Andrew T. McKie and Robert J. Simpson
HFE / Robert E. Fleming [and others]
Regulation of iron homeostasis by iron regulatory proteins 1 and 2 / Eric S. Hanson and Elizabeth A. Leibold
Iron-response element (IRE) structure and combinatorial RNA regulation / Hans E. Johansson and Elizabeth C. Theil
Frataxin and mitochondrial iron / Pierre Rustin
Siderophore chemistry / Alain Stintzi and Kenneth N. Raymond
Iron chelator chemistry / Zu D. Liu and Robert C. Hider
II. Cellular Iron Transport
Iron acquisition in plants / Elizabeth E. Rogers and Mary Lou Guerinot
Iron uptake in yeast / Orly Ardon, Jerry Kaplan, and Brooke D. Martin
Bacterial iron transport / Volkmar Braun and Klaus Hantke
Uptake of transferrin-bound iron by mammalian cells / Deborah Trinder and Evan Morgan
Transport of non-transferrin-bound iron by hepatocytes / Joel G. Parkes and Douglas M. Templeton
Iron acquisition by the reticuloendothelial system / Günter Weiss
Iron transport in the central nervous system / Joseph R. Burdo and James R. Connor
Iron uptake by neoplastic cells / Des R. Richardson
Novel methods for assessing transport of iron across biological membranes / Z. Ioav Cabantchik, Silvina Epsztejn, and William Breuer
III. Physiology of Iron Transport
Regulation of intestinal iron transport / Gregory J. Anderson and Christopher D. Vulpe
Regulation of systemic iron transport and storage / Pierre Brissot, Christelle Pigeon, and Olivier Loréal
Regulation of liver iron metabolism / Gaetano Cairo
Iron utilization in erythrocyte formation and hemoglobin synthesis / Prem Ponka
IV. Disorders of Iron Transport
Animal models of iron transport and storage disorders / Nancy C. Andrews.
Hemochromatosis : diagnosis and management following the discovery of the gene / Paul C. Adams
Transfusional iron overload / Nancy F. Olivieri
Aceruloplasminemia / Nathan E. Hellman and Z. Leah Harris
Hereditary hyperferritinemia cataract syndrome / Carole Beaumont and Domenico Girelli
Other disorders of increased iron absorption : iron overload in Africans and African Americans / Fitzroy W. Dawkins and Victor R. Gordeuk
Iron chelation / Chaim Hershko, Gabriela Link, and Avraham M. Konijn
Marcel Dekker, Hardback, english, 827 pages